Acts Fast, Doesn't Linger
The antihistamine, Diphenhydramine Hydrochloride, in Children’s Paedamin Decongestant and Antihistamine is what sets this product apart from other medicated cold products for kids like Demazin Syrup and Dimetapp Elixir.
Diphenhydramine Hydrochloride has been shown to provide noticeable relief within 15 minutes* and provides fast relief of symptoms like sneezing and itchy, watery eyes. It has a much shorter half-life that the antihistamines in Demazin Syrup and Dimetapp Elixir.
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Children’s Paedamin Decongestant and Antihistamine
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Demazin Cold Relief
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Dimetapp Elixir
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Active Ingredient
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Diphenhydramine Hydrochloride
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Chlorpheniramine Maleate
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Brompheniramine Maleate
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Half Life in Children:
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3.6-7.2 hrs
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6.8-19.4 hr
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11.3-13.5 hrs
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The shorter the half-life the better it is for kids because side-effects are reduced.
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References:
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Simons, KJ, et al.J Clin Pharmacol.1990; 30.
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Estelle, F et al. J Allergy Clin Immunol, 1982, 69(4).
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Estelle, F et al. Allergy Clin Immunol, 1999, 103(2).
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Half-life is quite a complex concept but basically it’s the time taken for the medication to be processed and eliminated by the body.
The shorter the half-life the better it is for kids because side-effects are reduced. A short half-life is beneficial because it means the medicine leaves your child’s system rapidly so they are less likely to experience grogginess the next day.
That means they can get back to the important business of playing sooner.
* Packman et al, Int J Clinical Pharmacol Ther Toxicol. 1991, 29 (60)